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The development of drugs targeting the CNS requires precise knowledge of their penetration into the brain 2 , and ideally, this information should be obtained as early as possible to avoid failure in late clinical development, when upward of $100 million is typically invested in a drug candidate

More serious risks to be aware of include: Pancreatitis: As with other GLP-1 receptor agonists, there is a theoretical and observed risk of acute pancreatitis

Zhou Y et al (2018) Autocrine Mfge8 signaling prevents developmental exhaustion of the adult neural stem cell pool

Access this article Similar content being viewed by others Data Availability All data generated or analyzed during this study are included in this published article

It must be stored in the refrigerator (2C to 8C or 36F to 46F) and typically used within 1428 days

10.1016/j.cell.2025.01.017 85 ShiF